Montana State University provided the necessary training and educational guidance to successfully inventory and lab-pack hazardous chemicals at 5 schools on the Cheyenne River Sioux Reservation. This work was accomplished in collaboration with the Cheyenne River Sioux Environmental Protection Department, Cheyenne Eagle Butte High School, Dupree School, Takini School, Timber Lake High School, and Tiospaye Topa School. Chemicals lab-packed include neurotoxins, carcinogens, suspected carcinogens, strong oxidizers, corrosive, caustic, toxic, ignitable, flammable, and potentially explosive chemicals. The school’s total student population is 668 and 84% Native American. A total of 1,750 pounds of chemicals were lab-packed by a hazardous waste broker and removed from the school system to a proper disposal/storage facility.